Mario Grotz started his career working for the Chamber of Commerce and the Chamber of Craft, where he acted as an advisor to SMEs in areas concerning business creation and business management. In 2001, he joined the Ministry of Economy where his main focus was on the evaluation of R&D projects implemented by the private sector.

From 2009-2012 he was appointed Head of the Directorate for Infrastructures and Technology. Since 2012 he has been the General Director for Research, Intellectual Property and New Technologies, responsible for the development of the technology based sectors in Luxembourg. Since 2012, he has served as Chairman of the Board of Directors of the company Creos Luxembourg.

In 2018, he became President of Luxinnovation, the national innovation agency, a position he will hand over in March 2025 to succeed Sasha Baillie as CEO of the agency.